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2017 GMC P0300: What It Means & Is It Safe to Drive?

P0300 on the 2017 GMC: Random/Multiple Cylinder Misfire Detected. Here's what it means, what usually causes it, what repairs typically cost, and whether it's safe to keep driving.

PowertrainHigh urgency

What this code means

The PCM has detected misfires across multiple cylinders. This can cause damage to the catalytic converter if driven for long.

Common causes on the 2017 GMC

  • Worn spark plugs or ignition coils
  • Clogged or bad fuel injectors
  • Low compression
  • Vacuum leak, bad MAF, or fuel delivery issue

Symptoms

  • Check Engine Light (often flashing under load)
  • Rough idle, shaking, loss of power
  • Possible smell of unburned fuel

Typical fixes

  • Replace spark plugs and coils as needed
  • Clean or replace fuel injectors
  • Fix vacuum/fuel issues
  • Compression test if no obvious cause

Repair cost range

For a 2017 GMC, repairs for P0300 typically fall between $150 and $1200, depending on the root cause and labor rates in your area.

Known issues on GMC

GMC Sierra P0300 on 5.3L LS V8 mirrors Silverado—AFM lifter collapse is the primary cause. When an AFM lifter fails, the PCM may not isolate it to a single cylinder P030X code; instead it logs P0300. Listen for a distinctive ticking at idle that confirms lifter failure. On Acadia 3.6L LLT/LGX V6, the timing chain tensioner can fail, causing cam timing variation and P0300. On Envoy 4.2L Atlas inline-six, the single coil pack cassette (all 6 cylinders on one cassette) fails systematically—a cheap fix that resolves P0300 immediately.

Most commonly affected models

Sierra 1500 5.3L V8 2007–2021Acadia 3.6L V6 2007–2017Envoy 4.2L L6 2002–2009

Is it safe to keep driving your 2017 GMC with this code?

For driving-safety guidance—how far you can go, when to tow, and what's urgent—see these checklists:

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