2022 Lexus P0300: What It Means & Is It Safe to Drive?
P0300 on the 2022 Lexus: Random/Multiple Cylinder Misfire Detected. Here's what it means, what usually causes it, what repairs typically cost, and whether it's safe to keep driving.
What this code means
The PCM has detected misfires across multiple cylinders. This can cause damage to the catalytic converter if driven for long.
Common causes on the 2022 Lexus
- Worn spark plugs or ignition coils
- Clogged or bad fuel injectors
- Low compression
- Vacuum leak, bad MAF, or fuel delivery issue
Symptoms
- Check Engine Light (often flashing under load)
- Rough idle, shaking, loss of power
- Possible smell of unburned fuel
Typical fixes
- Replace spark plugs and coils as needed
- Clean or replace fuel injectors
- Fix vacuum/fuel issues
- Compression test if no obvious cause
Repair cost range
For a 2022 Lexus, repairs for P0300 typically fall between $150 and $1200, depending on the root cause and labor rates in your area.
Known issues on Lexus
Lexus P0300 on 3.5L 2GR-FE V6 engines is uncommon before 120k miles. When it occurs, inspect coil-on-plug boots—the rubber boots degrade and allow moisture to short the coils in plug wells. On 2GR-FSE direct-injection engines (IS350, GS350), carbon buildup on intake valves combined with D4-S direct injection causes lean misfires. Lexus recommends walnut blasting at 80k+ intervals on FSE engines. On GX470 4.7L 2UZ-FE V8, P0300 is uncommon and usually indicates a failing ignition coil or spark plug in an inaccessible rear cylinder.
Most commonly affected models