2022 Lexus P0305: What It Means & Is It Safe to Drive?

P0305 on the 2022 Lexus: Cylinder 5 Misfire Detected. Here's what it means, what usually causes it, what repairs typically cost, and whether it's safe to keep driving.

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What this code means

Misfire on cylinder 5—present on V6, V8, and inline-5 engines only. On V6 engines, cylinder 5 is sometimes harder to access; factor labor into repair estimates.

Common causes on the 2022 Lexus

  • Fouled spark plug
  • Failed ignition coil
  • Leaking or clogged injector
  • Low compression from valve or ring wear

Symptoms

  • Check Engine Light
  • Engine shaking or rough idle
  • Power loss under acceleration

Typical fixes

  • Replace spark plug and coil on cylinder 5
  • Test and replace injector if needed
  • Compression and leak-down test

Repair cost range

For a 2022 Lexus, repairs for P0305 typically fall between $150 and $1000, depending on the root cause and labor rates in your area.

Known issues on Lexus

Lexus 2GR-FSE P0305 on rear-bank cylinder 5 is typically a failed COP coil. Access requires intake manifold removal. Confirm the fault before disassembly—a coil swap to the front bank confirms the misfire follows the coil. These engines are otherwise extremely reliable.

Most commonly affected models

GS350 2GR-FSE 2007–2011IS350 2GR-FSE 2006–2013RC350 2GR-FSE 2015–2020

Is it safe to keep driving your 2022 Lexus with this code?

For driving-safety guidance—how far you can go, when to tow, and what's urgent—see these checklists:

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