What does code P0300 mean on a Nissan and is it safe to drive?
P0300: Random/Multiple Cylinder Misfire Detected. Here's what it means on your Nissan, what usually causes it, what repairs typically cost, and how safe it is to keep driving.
What this code means
The PCM has detected misfires across multiple cylinders. This can cause damage to the catalytic converter if driven for long.
Common causes for your Nissan
- Worn spark plugs or ignition coils
- Clogged or bad fuel injectors
- Low compression
- Vacuum leak, bad MAF, or fuel delivery issue
Symptoms
- Check Engine Light (often flashing under load)
- Rough idle, shaking, loss of power
- Possible smell of unburned fuel
Typical fixes
- Replace spark plugs and coils as needed
- Clean or replace fuel injectors
- Fix vacuum/fuel issues
- Compression test if no obvious cause
Repair cost range
For a Nissan, repairs for P0300 often fall between $150 and $1200, depending on the cause and whether you use OEM or aftermarket parts. Labor rates vary by location.
Known issues on Nissan
Nissan P0300 on VQ35DE 3.5L (Maxima, Altima V6, Murano) is commonly caused by ignition coil failure—VQ35 coils fail systematically; replace all six coils and plugs when one fails to prevent repeated P0300 codes. On QR25DE 2.5L Altima, a wobbling crankshaft reluctor wheel is a known defect that produces P0300 combined with P0335—if both codes are present together, the reluctor wheel should be inspected. On Pathfinder VQ40, clean the throttle body if P0300 appears at idle.
Most commonly affected models