What does code P0301 mean on a Mercedes-Benz and is it safe to drive?

P0301: Cylinder 1 Misfire Detected. Here's what it means on your Mercedes-Benz, what usually causes it, what repairs typically cost, and how safe it is to keep driving.

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What this code means

The PCM has detected a misfire specifically on cylinder 1. Similar to P0300, but pinned to a single cylinder.

Common causes for your Mercedes-Benz

  • Worn or fouled spark plug on cylinder 1
  • Failing ignition coil or coil-on-plug
  • Leaking or clogged fuel injector
  • Low compression in cylinder 1

Symptoms

  • Check Engine Light (often flashing when misfire is severe)
  • Rough idle or shaking, especially at low RPM
  • Loss of power under load

Typical fixes

  • Replace spark plug and/or coil on cylinder 1
  • Test and clean or replace the injector
  • Perform compression test and repair internal issues if needed

Repair cost range

For a Mercedes-Benz, repairs for P0301 often fall between $150 and $900, depending on the cause and whether you use OEM or aftermarket parts. Labor rates vary by location.

Known issues on Mercedes-Benz

Mercedes M272 V6 P0301 is often related to the balance shaft gear failure—a known and expensive issue on M272 engines built before 2008. A worn balance shaft gear can cause timing irregularities that trigger cylinder-specific misfires. Verify balance shaft timing before condemning the ignition system.

Most commonly affected models

C300 M272 2007–2012E350 M272 2006–2012ML350 M272 2006–2011

Is it safe to keep driving your Mercedes-Benz with this code?

For driving-safety guidance—how far you can go, when to tow, and what's urgent—see these checklists:

Browse P0301 on your Mercedes-Benz by model year

Year-specific guides include Mercedes-Benz-tailored causes and repair costs.

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